Arizona Cardinals Schedule: Must-See Matches of 2022-23 NFL Season

It’s a good thing Kyler Murray and the Arizona Cardinals like the bright lights because they’ll be spending almost a quarter of their season in primetime this year.

The Cardinals have four primetime games in 2022, highlighted by a Monday night match in Mexico City against the 49ers and a Christmas Day duel against Tom Brady and the Bucs. 

It’s the most primetime games the Cards have had since 2016 and a chance for them to show the nation what they’re all about this year. 

With NFL kickoff fast approaching, here’s a look at the Cardinals’ schedule and a sneak peek at a few can’t-miss games.

Arizona Cardinals Schedule

WeekOpponentDate/Time (Station)
Week 1vs. Kansas City ChiefsSept. 11 at 1:25 p.m. (CBS)
Week 2at Las Vegas RaidersSept. 18 at 1:25 p.m. (CBS)
Week 3vs. Los Angeles RamsSept. 25 at 1:25 p.m. (FOX)
Week 4at Carolina PanthersOct. 2 at 1:05 p.m. (FOX)
Week 5vs. Philadelphia EaglesOct. 9 at 1:25 p.m. (FOX)
Week 6at Seattle SeahawksOct. 16 at 1:05 p.m. (FOX)
Week 7vs. New Orleans SaintsOct. 20 at 5:15 p.m. (AMAZON PRIME VIDEO)
Week 8at Minnesota Vikings Oct. 30 at 10 a.m. (FOX)
Week 9vs. Seattle Seahawks Nov. 6 at 2:05 p.m. (FOX)
Week 10at Los Angeles RamsNov. 13 2:25 p.m. (FOX)
Week 11vs. San Francisco 49ers at Mexico CityNov. 21 at 6:15 p.m. (ESPN)
Week 12vs. Los Angeles ChargersNov. 27 at 2:05 p.m. (CBS)
Week 13Bye Week
Week 14vs. New England PatriotsDec. 12 at 6:15 p.m. (ESPN)
Week 15at Denver BroncosDec. 18 at 2:05 p.m. (FOX)
Week 16vs. Tampa Bay BuccaneersDec. 25 at 6:20 p.m. (NBC)
Week 17at Atlanta FalconsJan. 1 at 11 a.m. (FOX)
Week 18at San Francisco 49ersJan. 8 at TBD (TBD)

Arizona Cardinals Odds to Win The Super Bowl

Arizona Cardinals Odds to Win The NFC West

Can’t Miss Games & Odds

WEEK 1- Sept. 11 CHIEFS at CARDINALS 1:25 p.m. (CBS)

So much for easing into the season. The Cardinals have one of the toughest schedules in the league this year, and it begins in Week 1 with the Kansas City Chiefs. The Chiefs might have lost Tyreek Hill, but make no mistake, this is still an elite squad. 

KC added crafty veteran JuJu Smith-Schuster to soak up some of the receptions vacated by Hill and selected dynamic wideout Skyy Moore in the second round of this year’s draft. This game will be an early treat for the fans, with two of the game’s most electric quarterbacks going head-to-head. 

Can Kliff Kingsbury devise a game plan to slow down the QB he used to coach in college? Cardinals fans are counting on it.

Week 1 Results

Chiefs – 44

Cardinals – 21

Betting results of the last three meetings

DateWinnerWinner H/AScoreATS CoverO/U Result
11/11/18Kansas CityHome26-14Arizona +16.5Under 49.5
12/07/14ArizonaHome17-14Arizona +3.0Under 41.5
11/21/10Kanasas CityHome31-13Kansas City -7.0Under 45.0

WEEK 3Sept. 25 RAMS at CARDINALS 1:25 p.m. (FOX)

After the Chiefs and Raiders in the first two weeks, it won’t get any easier in Week 3 when the Super Bowl champs roll into town. These divisional foes know each other well, and the Cardinals will be looking to knock the Rams off their pedestal and make an early season statement. 

The Rams have won the last two matchups by a combined 30 points, covering both point spreads with ease. Kyler Murray better have his laces tied tight for this one because Aaron Donald is likely to be a problem all night long. 

Two of the previous three games between these two have hit the over, with their most recent contest narrowly missing with 45 combined points. You can expect more fireworks in this one as both offenses will have had a couple of games to get tuned up.

Week 3 Odds

Betting results of the last three meetings

DateWinnerWinner H/AScoreATS CoverO/U Result
12/13/21LA RamsAway30-23LA Rams +3.0Over 51.0
10/03/21ArizonaAway37-20Arizona +3.5Over 54.0


It’s a rare game against the new-look New Orleans Saints in Week 7, as these two only play once every three years. The Saints have had bad luck with the injury bug recently, but Michael Thomas and Jameis Winston are finally healthy and ready to rock. NO also added sure-handed slot receiver Jarvis Landry in the offseason and drafted the Ohio State Buckeye burner Chris Olave

The Saints have taken the last two matches dating back to 2016, so the Cardinals will be looking to get off the schneid. Many analysts are picking New Orleans as a dark horse to win their division this year, and they certainly have the talent to make some noise. 

Week 7 Odds

Betting results of the last three meetings

DateWinnerWinner H/AScoreATS CoverO/U Result
10/27/19New OrleansHome31-9NO -12.5Under 48.0
12/18/16New OrleansAway48-41NO +3.0Over 48.0
09/13/15ArizonaHome31-19Arizona -2.5Over 48.5

WEEK 11Nov. 21 CARDINALS vs. 49ERS at Mexico City 6:15 p.m. (ESPN)

Que Bueno! It’s going to be a fiesta in Mexico City when the Cardinals take on the divisional rival 49ers in a Monday night showdown at Estadio Azteca. These two squared off in Mexico back in 2005 in the NFL’s first-ever regular-season game outside of the United States. 

This will be a crucial game for the Cardinals as they’ll be looking to have a strong run down the stretch, something they haven’t been able to do in recent history. The 49ers have one of the most well-rounded teams in the league, but the Cards will likely have to at least split the season series if they plan on making the postseason this year

Week 11 Odds

Betting results of the last three meetings

DateWinnerWinner H/AScoreATS CoverO/U Result
11/07/21ArizonaAway31-17Arizona +5.5Over 44.5
10/10/21ArizonaHome17-10Arizona -6.0Under 48.5
12/26/20San FranciscoAway20-12SF +6.0Under 49.0

WEEK 16Dec. 25 BUCCANEERS at CARDINALS 6:20 p.m. (NBC)

Santa Claus might be coming to town, but so is Tom Brady. Arizona will host the Tampa Bay Buccaneers on Christmas night, and Brady will be bringing all his little helpers with him. The Bucs have a loaded roster that features Mike Evans, Chris Godwin, and a bruising running game led by Leonard Fournette. 

They do have some issues with their offensive line right now, so we’ll see if they can figure that out over the next few months. This game could have serious playoff implications for both teams with the season winding down. To be the best, you have to beat the best – and Kyler Murray will be looking to take down the GOAT in what should be an instant Christmas classic.

Week 16 Odds

Betting results of the last three meetings

DateWinnerWinner H/AScoreATS CoverO/U Result
11/10/19Tampa BayHome30-27NO -12.5Over 51.5
10/15/17ArizonaHome38-33Arizona +5.Over 46.5
09/18/16ArizonaHome40-7Arizona -7.0Under 49.5



Photo by Ian Johnson/Icon Sportswire

About the Author

Ryan Hagen

Ryan Hagen is a writer for Arizona Casinos. He’s spent most of his career writing in various roles and copywriting for various industries. Ryan's passion is sports, and that has been his focus, writing in the sports betting industry for the last few years.