Arizona Cardinals Vs. San Francisco Odds For Mexico City Game

We might be 200 days away from the Arizona Cardinals and San Francisco 49ers meeting for a Monday Night Football Game in Mexico City on Nov. 21, but odds for that game are already on the board from DraftKings Arizona. That means you can start sharpening your NFL betting strategy. Other Arizona sports betting apps are likely to release their own point spreads for this game and others in the near future.

The Cardinals’ odds to win Super Bowl LVII are listed at +2500 by DraftKings Arizona. If they wish to get that far, they’ll need to handle the 49ers, a division rival they play twice each season. Of course, the defending Super Bowl champs, the Los Angeles Rams, are also in the NFC West.

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Arizona Cardinals Vs. San Francisco Odds In Mexico City

The international Cardinals-49ers game will be played in Estadio Azteca on Nov. 21, with kickoff at 6:15 p.m. MT.

It will be the only primetime NFL game on the schedule to be played in a foreign country. The broadcast will be on ESPN as part of its Monday Night Football programming.

Here are odds for the game, per DraftKings Arizona Sportsbook, as of Thursday afternoon:

San Francisco 49ers-2.5 -110OVER 48 (-110)-135
Arizona Cardinals+2.5 -110UNDER 48 (-110)+115

This will be the fifth NFL game played in Mexico but the first since 2019. Each of the games has been played at historic Estadio Azteca, which sits more than 7,200 feet above sea level. Since 2007, the NFL International Series has scheduled games in foreign nations, including the United Kingdom, Mexico, and Germany.

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Cardinals Thumped 49ers Twice Last Season

The 2021 season was an unequivocal success for Arizona. The Cardinals had 11 wins and made their first playoff appearance in six seasons with an impressive performance on both sides of the pigskin during the regular season. With QB Kyler Murray and coach Kliff Kingsbury leading the way, the “K’s” have it for this team, which is on the upswing as a contender.

Last year, Arizona ranked eighth in the league in offensive yards, 11th in defense, and fourth in turnover ratio. The team started 7-0, and even though it was sent home after being soundly beaten by the Rams in the playoffs, Murray and Co. are clearly poised to be a problem for teams in the NFC for a while.

Twice last year the Cards beat the 49ers by a combined score of 48-28. Arizona finished one game ahead of San Francisco in the NFC West, and in each game they played in 2021, the Cardinals were the more disciplined and physical team.

The Cardinals have won 11 of the last 14 meetings between these two teams. The Cards have been so successful against their rivals of late that the all-time series is now at 29-32, with Arizona inching up on drawing even with “That Team From The Bay.”

A notable question for the 49ers will be at QB. Will Trey Lance take a firm grip on the starting job in his second year? He’s started two games in the NFL, and Matt Lombardo is reporting that the 49ers staff are concerned about his development.


Should he not be ready for primetime, Lance will yield to veteran signal-caller Jimmy Garoppolo, assuming he is not traded in the coming months. Garoppolo somehow never gets respect, despite being 33-14 in the league.

Murray should be giddy at his prospects for the 2022 season, with new targets, including four-year veteran wide receiver Marquise Brown and rookie tight end Trey McBride in his huddle. The Cardinals could be more of a downfield threat, and the team also added two linemen in the NFL Draft to bolster protection for Murray.

About the Author

Dan Holmes

Dan Holmes has written three books about sports. He previously worked for the National Baseball Hall of Fame and Major League Baseball. He enjoys writing, running, and lemon bars. He lives near Lake Michigan with his daughters and usually has an orange cream soda nearby.