Arizona Cardinals Vs. San Francisco 49ers NFL Betting Odds

After the Arizona Cardinals had a big division win last Sunday, they are on to another division game, this time hosting the 49ers.

I knew the Cardinals were going to come out and dominate against the LA Rams and that is exactly what they did. Now, the Cardinals are the only undefeated team at 4-0.

With two of the 49ers’ top players out this week, I think the Arizona Cardinals are going to be 5-0 after Sunday.

SF 49ers vs ARI Cardinals Moneyline Point Spread Total Points
SF 49ers +3500 +6.0 (-110) U 24.5 (-125)
ARI Cardinals -10000 -6.0 (-120) O 24.5 (-105)
Odds updated: October 10, 4:27pm PDT
SF 49ers vs ARI Cardinals Moneyline Point Spread Total Points
SF 49ers +2000 +7.0 (+120) U 48.5 (-110)
ARI Cardinals -5000 -7.0 (-149) O 48.5 (-110)
Odds updated: October 10, 4:27pm PDT

*Odds provided by Caesars Sportsbooks. Claim up to $5,000 in risk-free bets

Cardinals Game Preview (4-0)

There is no denying that the Cardinals are on fire and Kyler Murray and the offense seems to be unstoppable. The offense has put up over 30 points in every game so far this season. And not only did the Cardinals surprise the world by beating the Rams in week 4, but they also beat them by double digits.

Murray threw two touchdowns and for 268 yards in week 4. But it was running back Chase Edmonds who stole the show with 120 rushing yards. Running back James Conner has been stepping into his role on his new team nicely, with two touchdowns and 50 rushing yards last week.

Another new player on the roster who has been helping the Cardinals is wide receiver A.J. Green. In addition to his leadership role, Green had one touchdown and 67 yards in the win against the Rams. The offensive line could see some improvement, allowing three sacks last game. But luckily Murray is good on his feet and has been able to get out of trouble for the most part.

The offense should have no trouble against the 49ers’ defense as long as they continue to play like they have been. The only thing I am worried about is the injuries. Running backs Chase Edmonds and Eno Benjamin along with tight end Maxx Williams are questionable for the game and will most likely be game-time decisions.

The defense continued to impress holding the Los Angeles Rams to only 20 points last week. But Byron Murphy Jr., who had an interception last week, is out for the game this week. But Arizona will still have Chandler Jones, J.J. Watt, and Markus Golden, just to name a few.

49ers Game Preview (2-2)

Quarterback Jimmy Garoppolo is out and that means Trey Lance will be starting. When Garoppolo exited the game last week due to an injury, Lance stepped in throwing for 157 yards and two touchdowns. Lance will need to watch out for Arizona’s defense since the 49ers allowed two sacks last week and we all know the Cardinals’ defense is much better than the Seahawks. But the Cardinals defense will need to stop Trey Sermon, who had 89 rushing yards last week, and Deebo Samuel, who had two touchdowns and 156 receiving yards. The team had trouble with third downs against the Seahawks, converting only two of 14. But they stepped up on fourth downs, converting three of four.

San Francisco ended up losing to the Seahawks in week 4 but held them to only 234 total yards. The defense had three sacks, two coming from Dee Ford and one from Nick Bosa. Overall, the 49ers looked pretty good, with the exception of the one fumble and interception, but I don’t think they have what it takes to beat the Cardinals at home.

There is no doubt that the 49ers are much better than they were last year, but that is because they were flooded with injuries last season. But it looks like the injuries could be coming back to haunt them, with Garoppolo out and also tight end George Kittle.

NFC West Division Odds

With a 4-0 record, the Cardinals are not just on top of the NFC West, they are on top of the NFC and the entire league. They also have one division win under their belt.

The Cardinals are proving to the league that they are the real deal and sports betting apps are finally taking notice. Arizona is now at +750 to win the NFC and +1600 to win the Super Bowl.

NFC Division Winner Odds By DraftKings

  • Rams +100
  • Cardinals +150
  • Seahawks +700
  • 49ers +900

How To Watch The Cardinals & 49ers Game

  • Date: Sunday, October 10
  • Time: 1:25 PM MST
  • Location: State Farm Stadium in Glendale, AZ
  • TV: Fox
    About the Author

    Calli Varner

    Calli is the editor and senior contributor of As a football fanatic and lifelong resident of Arizona, she proudly cheers on the Arizona Cardinals. But her heart belongs to her number one team, the Kansas City Chiefs. (Go Chiefs Kingdom!) You can follow Calli on Twitter at @CalliDoesSports.